Cell and gene therapy studies present some of the most complex operational challenges in clinical research. Personalized manufacturing, strict treatment timelines, long-term follow-up, and specialized site workflows require technology that can adapt to highly individualized participant journeys while maintaining regulatory compliance and high-quality data collection.

Advancing Digital Health Technology with Research Expertise

Technology and consulting tailored for device-focused and MedTech clinical studies.

Purpose-built technology and consulting support for pediatric clinical research.

Phase 2 and Phase 3 trials generate the evidence that determines whether therapies move toward approval. As studies expand across countries, sites, participants, and endpoints, operational complexity increases significantly. THREAD helps sponsors and CROs simplify execution with a single configurable platform designed to support global, hybrid, and decentralized clinical trials while reducing burden for participants, sites, and study teams.

Phase 3b and Phase 4 studies extend beyond regulatory approval to evaluate long-term safety, effectiveness, treatment adherence, quality of life, and real-world outcomes. As studies become larger, longer, and more decentralized, THREAD helps sponsors simplify execution with a single configurable platform that supports global post-approval research while improving participant engagement and data quality.

A fit-for-purpose clinical research foundation for long-term registry programs.

Our portfolio of cardiovascular studies has supported complex protocols and at-risk populations along with studies that overlap with critical indications like obesity. Our approach to the unique data monitoring and alert requirements in cardiovascular studies integrates wearables, sensors, and connected devices to enable real-time data collection and proactive alerting. These technologies not only support remote monitoring but also enhance patient engagement and allow for faster, more informed decision-making—bringing greater precision and responsiveness to cardiovascular research.

Dermatology study designs often require precise, visual assessments and ongoing communication between participants and study teams. To meet these needs, we leverage video telehealth visits and remote image capture capabilities, enabling high-quality data collection and enhancing participant engagement—whether at home or on the go. THREAD’s technology-driven approaches combined with flexible eCOA reduce site burden, support more inclusive participation, and allow for real-time evaluation of skin-related outcomes, helping ensure trials are both efficient and patient-centered.

Gastroenterology studies often require frequent symptom tracking, medication adherence monitoring, electronic diaries, laboratory assessments, imaging, endoscopy visits, and long-term participant engagement. THREAD's no-code configurable platform enables sponsors to rapidly deploy studies while easily adapting to protocol amendments without custom development.

Hematology studies often involve complex treatment regimens, specialized clinical assessments, long-term safety monitoring, and highly individualized participant journeys. From leukemia, lymphoma, multiple myeloma, and myelodysplastic syndromes to sickle cell disease, hemophilia, thrombosis, and other rare blood disorders, sponsors need flexible technology that simplifies study execution while supporting high-quality clinical and patient-reported data collection.

Autoimmune and inflammatory disease studies often require frequent symptom reporting, quality-of-life assessments, medication tracking, laboratory monitoring, and years of participant follow-up. THREAD's no-code configurable platform enables sponsors to rapidly deploy studies while easily adapting to protocol amendments without custom development.

Infectious disease studies demand speed, flexibility, and the ability to reach diverse populations across geographies. Whether responding to emerging outbreaks, evaluating vaccines, or supporting therapies for chronic infectious conditions, sponsors must rapidly activate studies while maintaining high-quality data collection, participant engagement, and regulatory compliance.

CNS trials, including Neurology and Psychiatry, have some of the lowest success rates compared to other therapeutic areas. There are many factors that contribute to this such as: Reliance on subjective endpoints, challenges with consenting, and patient burden due to long trial durations. THREAD understands these challenges and has a proven track record supporting these trials through a holistic approach. We have found that it is necessary to select and develop new endpoints, while listening to patients, taking into account their unique considerations, making research better overall. With over 30 rare disease neurology studies including those with severe neurodegeneration, our teams understand the complex support required to ensure participants and their care teams stay engaged and data is collected reliably on time.

Obesity and diabetes research often relies on frequent data collection, long study durations, connected health technologies, and ongoing participant engagement. THREAD's no-code configurable platform enables sponsors to rapidly deploy studies while adapting to protocol changes without custom development.

Experience supporting oncology research with flexible participant and caregiver workflows.

Ophthalmology studies require precise endpoint collection, frequent participant follow-up, and the ability to coordinate data from clinics, imaging systems, connected devices, and participants themselves. From retinal diseases and glaucoma to dry eye disease, inherited retinal disorders, and emerging gene and cell therapies, sponsors need flexible technology that simplifies study execution while improving participant engagement and data quality.

Respiratory studies often require frequent symptom reporting, home-based monitoring, device integrations, and long-term participant engagement. THREAD's no-code configurable platform enables sponsors to rapidly deploy studies while easily adapting to protocol amendments without custom development.

Rare disease research support designed for dispersed populations and complex care journeys.