Improving How Treatment Adherence and Satisfaction Are Measured in HIV Care
Understanding real-world patient experience to inform better measurement and decision-making in existing Patient-Reported Outcomes and development of new conceptual models
The Modus Solution
Research consultancy specializing in patient-centered outcomes, helping life sciences organizations measure and understand treatment experiences through qualitative and quantitative research.
HOW WE DID IT
Overview
How do people with HIV (PHV) actually experience treatment adherence and satisfaction and are we measuring it correctly?
This study explored gaps in existing patient-reported outcome (PRO) measures and developed new conceptual models grounded in real patient and clinician perspectives.
The result: a clearer, more actionable understanding of what drives adherence and satisfaction in modern HIV treatment.
DELIVER
Our Approach
We brought together literature, clinical expertise, and patient voice into a unified research effort to complete:
- Targeted literature review
Assessing existing adherence and satisfaction frameworks and PRO instruments - Expert consultation
Interviews with clinicians to understand treatment realities and unmet measurement needs - Qualitative patient research
In-depth interviews with 27 people living with HIV (PWH) to capture real-world perspectives on treatment experience
The Solution
By synthesizing insights across research and stakeholder groups, we helped:
- Identify gaps in how adherence and satisfaction are currently measured
- Surface patient-centered drivers often missed in traditional instruments
- Map existing PRO measures against real-world concepts to evaluate coverage
THE OUTCOME
The study delivered two new conceptual models:
- Treatment Adherence Model
Capturing treatment-related, behavioral, and contextual drivers - Treatment Satisfaction Model
Reflecting both medication experience and broader system-level influences
Additional Results
- Conducted item-to-concept mapping across 9 PRO instruments
- Identified key areas where existing tools fall short in capturing patient experience
These outputs provide a stronger foundation for future measurement, research, and product strategy in HIV care.